Association of G22A variant of Adenosine Deaminase gene with coronary in-stent restenosis in coronary artery patients receiving drug-eluting stent

In-stent restenosis (ISR) is regarded as the main problem in the utilization of stents in the treatment of coronary artery atherosclerotic stenosis in percutaneous coronary intervention (PCI). This study investigated the possible role of the G22A variant of the Adenosine Deaminase gene (ADA) in the development of ISR. In this study, 91 patients who underwent PCI were divided into two groups of case with ISR (n=40) and control without ISR after six months from stenting (n=51). The case and control groups were matched in terms of age and gender. The genotypes of the G22A variant in the samples were examined by the molecular method of PCR-RFLP and electrophoresis. The results were statistically analyzed using t-test, and the results showed that the frequency of allele A of variant G22A in the (+ISR) group was higher than that in the (-ISR) group. However, there was no significant relationship between the distribution of allele and genotype frequency of this variant with the incidence of ISR (P>0.05).